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Other properly studied nAChR genes embrace the CHRNA4 and CHRNB2, which have been related as Autosomal Dominant Nocturnal Frontal Lobe Epilepsy (ADNFLE) genes. Studies identified a number of CHRNA7 promoter polymorphisms that reduce the genes transcriptional exercise to be related to schizophrenia, which is in line with the finding of lowered levels of a7 nAChRs within the brain of schizophrenic patients. Several research have reported an association between CHRNA7 and endophenotypes of psychiatric disorders and nicotine dependence, contributing to the numerous clinical relevance of α7 and research being accomplished on it.

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